Northwestern scientists are leading the charge to sequence proteins the way the Human Genome Project sequenced genes and DNA. A recent study in Science confirms they are on to something big. Neil Kelleher, PhD, has been weighing proteins since 1999, when, as a young professor, he opened his […]
Setting audacious goals for technology innovation is a critical component of the Human Proteoform Project, a $1.3 billion movement to weigh and characterize every protein variation, (called proteoforms) in the human body. A new technology announced today, co-developed by Northwestern’s Neil Kelleher, director of Northwestern Proteomics and Chemistry of Life Processes […]
Proteomics is a broad term that can generically be defined as the study of the proteome, or the landscape of proteins expressed within a given biological context. More specifically, proteomics can entail investigating aspects of the proteome such as protein expression levels, post-translational modifications (PTMs), cellular […]
Northwestern University scientist have discovered families of proteins in the body that could potentially predict which patients may reject a new organ transplant, helping inform decisions about care. The advancement marks the beginning of a new era for more precise study of proteins in specific cells. […]
Eight years ago, an international team of researchers proposed that the term “proteoform” be adopted to describe the vast number of forms of protein products from our genes—including changes due to genetic variations, alternative RNA splicing, and post-translational modifications—to reduce the semantic-related ambiguity in the study […]
Chemistry of Life Processes Institute has selected two high-risk, potentially high-reward biomedical research projects to receive CLP Cornew Innovation Awards. The 2021-22 awards will support the development of new technology for creation of viral nanoparticles for gene therapy and research to identify proteins distinguishing ALS pathology in […]
Methods of antibody detection are used to assess exposure or immunity to a pathogen. Here, we present Ig-MS, a novel serological readout that captures the immunoglobulin (Ig) repertoire at molecular resolution, including entire variable regions in Ig light and heavy chains. Ig-MS uses recent advances in […]
This episode of Northwestern University Feinberg School of Medicine’s Breakthroughs Podcast features Neil Kelleher, PhD, director of Northwestern Proteomics and Chemistry of Life Processes Institute. Millions of molecular proteins are swimming through our body’s cells and many studies have discovered that these proteins are the main […]
The Human Proteoform Atlas (HPfA) is a web-based repository of experimentally verified human proteoforms on-line at http://human-proteoform-atlas.org and is a direct descendant of the Consortium of Top-Down Proteomics’ (CTDP) Proteoform Atlas. Proteoforms are the specific forms of protein molecules expressed by our cells and include the unique combination […]
Now that the Human Genome Project has officially wrapped, an international team of researchers will map the entire collection of proteins in the human body. Plans and goals for the Human Proteoform Project were outlined in a paper published last week (Nov. 12) in the journal Science Advances. […]
The Human Genome Project (HGP) was a remarkable and unqualified success profoundly transforming and accelerating biological and medical research while converting a ~ $4B public investment into over $700B of economic activity and new industries (1). The challenge of revealing the “Blueprints of Life,” however, is surpassed by […]
Renowned proteomics expert Neil L. Kelleher has been named director of the Chemistry of Life Processes Institute (CLP), effective Sept. 1. Kelleher succeeds Thomas O’Halloran, who led CLP since it launched in 2005. Kelleher is the Walter and Mary Glass Professor of Molecular Biosciences and professor of chemistry in the […]
Sugars are found in cells and on the cell surface. The Human Proteoform Project will include mapping glycoproteoforms. Nucleic acids, proteins, lipids and small molecules are major constituents of the human cell but as molecular biology barreled ahead in terms of progress, another major class of […]
Participants in a NIH Workshop on Functional and Integrative Proteomics Abstract. All human diseases involve proteins, yet our current tools to characterize and quantify them are limited. To better elucidate proteins across space, time, and molecular composition, we provide provocative projections for technologies to meet the […]
On June 29, 2021, Neil L. Kelleher, PhD, director of Northwestern Proteomics and Chemistry of Life Processes Institute, gave a Zoom presentation, entitled “Case Studies of Proteoforms in Human Health and Disease” at a biannual Translational Applications in Medical Research Lecture event sponsored by at the […]